Our Services

Divergene works closely with CDMOs and gene therapy companies to support their next-generation sequencing capability from upstream vector engineering to downstream vector QC

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End-to-end Sequencing

Whether you are looking for AAV capsid library enrichment or interested in post-infection solutions, Divergene utilizes the latest technologies on the market, including PacBio® long-read (>10kb) and Illumina® short-read sequencing, to provide custom, in-depth solutions for complex AAV gene therapy applications.

  • AAV Sequencing
  • Vector Discovery
  • Confirm Plasmid Sequences
  • Quantify AAV Expression
  • Validate Packaged Material
  • Monitor Host Response
  • Single Cell Sequencing
  • Transcriptome Analysis

If any of the applications interest you, get in touch with us or
Order on Science Exchange.


Divergene solutions streamline AAV cell and gene therapy research by providing a comprehensive approach. These solutions are optimized for adeno-associated virus (AAV) applications and include a proprietary QC process. With Divergene, researchers can easily verify the integrity of packaged AAV vectors, measure AAV expression post-infection, monitor host response, and more. Divergene’s technologies, such as PacBio® long-read (>10kb) and Illumina® short-read sequencing, are used to provide customized and in-depth solutions for complex AAV gene therapy applications.

QC & Library Preparation


Bioinformatics Analysis

Custom NGS Analysis Pipeline Development

We’re experts on bioinformatics software; if you want something built, you probably want us. And we will deliver.

1. Do you need software to support your sequencing platform?
2. Do you need software that performs custom analysis of NGS data?
3. Do you need software that manages existing bioinformatics workflows?
4. Do you need your existing bioinformatics workflows tested and/or standardized?
5. Do you need to make your software clinical-grade for FDA submission or backed by escrow agent ?

If you answered yes to one or more of these questions, get in touch with us or
Order on Science Exchange.

Why Choose Us

Superior Speed & Data Quality

Robust framework, stringent quality control producing high-quality data

Ph.D.-Level Support

From start to finish, our experienced team provides insight and responses within hours

Customized solutions

From wet lab to dry lab, we provide support at every level and actionable dashboards/reports

cell & gene therapy focus

Trusted partner for top cell and gene therapy biotechs and biopharma


Divergene utilizes Illumina and other cutting-edge NGS platforms. For information on our NGS platforms as well as recommended configurations of your projects, please contact us.


Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras

Discover how researchers utilized single molecule, real-time (SMRT®) sequencing to profile rAAV-packaged genomes and assess full-length integrity for rAAV quality control.

Direct ITR-to-ITR Nanopore Sequencing of AAV Vector Genomes

Nanopore sequencing is a quick and low-cost alternative that can obtain full-length resolution of encapsidated genomes, although with low accuracy and high miscalling rates.

Advanced Characterization of DNA Molecules in rAAV Vector Preparations by Single-stranded Virus Next-generation Sequencing

In this study, learn how short-read sequencing technology can extensively characterize the rAAV genome while simultaneously detecting the presence of DNA contaminants.

Human and Insect Cell-Produced Recombinant Adeno-Associated Viruses Show Differences in Genome Heterogeneity

The exact genome compositions of full, intermediate, and empty capsids remain unknown, but recent AAV-genome sequencing reveals surprising findings on vector efficacy and safety.

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